Damon Wayans and Adam Sandler star in this comedic adaptation of The Defiant Ones (1958). An undercover cop (Wayans) becomes friends with one of the henchmen (Sandler) in the crime organization he has infiltrated. But when his cover is blown, he winds up in the hospital and his friend at odds with his boss. Now the cop has to get his ex-friend across the country to speak as a witness against the crime lord. But can these former friends and now bitter enemies make it there while evading the kingpins assassins?